Review Article

Release of Inflammatory Mediators by Human Adipose Tissue Is Enhanced in Obesity and Primarily by the Nonfat Cells: A Review

Figure 3

The effect of obesity on total release of 6 adipokines by explants of adipose tissue from obese women. The data are from the report by Fain et al. [42] for release of 6 adipokines by adipose tissue from 22 women divided into tertiles. The lowest tertile was composed of 7 women with total fat masses of 18 to 40 kg with a mean of 29 kg. The middle tertile was composed of fat from 8 women with total fat masses ranging from 41 to 52 kg with a mean of 49 kg. The highest tertile was fat from 7 women with fat masses ranging from 56 to 75 kg (mean of 65 kg). The ratio of total release by the highest tertile as compared to the lowest tertile is shown and all ratios were significant with a P<.001 except for zinc α2 glycoprotein [ZAG] release that was not statistically significant (P>.05).
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