Toll-like Receptor 4 Modulation as a Strategy to Treat Sepsis

Table 1

Some of the natural inhibitors of TLR4 signalling.

Level of action	Natural TLR4 signaling inhibitor
Extracellular	Soluble CD14	sCD14
	Soluble MD2	sMD2
	Soluble TLR4	sTLR4
Membrane	Receptor RP105	RP 105
	TNF-Related Apoptosis Inducing Ligand-Receptor	TRAIL-R
	Receptor ST2	ST2
Intracytoplasmic
(i) MyD88	Short form of MyD88	MyD88s
	Single Immunoglobulin Il-1 Receptor-related molecule	SIGIRR
(ii) IRAK	Interleukin-1 receptor associated kinase M	IRAK M
	Monarch 1
	Toll Interacting Protein	TOLLIP
(iii) TRAF-6	A20
	β-arrestin
(iv) P38 and JNK kinases	Phosphatidyl inositol 3 kinase	PI3K
(v) NF$\kappa$B	A20-binding inhibitor of NFκB activation	ABIN-3
	p50 and Mel B dimers
(vi) Cytokine secretion	Suppressor of cytokine secretion 1	SOCS1