Toll-like Receptor 4 Modulation as a Strategy to Treat Sepsis

Table 2

Mode of action of various molecules targeting TLR4.

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Molecules interfering with TLR4 and TLR4-mRNA expression

 (1) Chloroquine

 (2) Ketamine

 (3) GTS21 (nicotinic analogue)

 (4) Statins

 (5) Vitamin D3 (?)

 (6) Lidocaine

 (7) Glycine

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Molecules interfering with TLR4-related intracellular signalling pathway

 (1) Eritoran (E5564)

 (2) Resatorvid (TAK242)

 (3) Ketamine

 (4) Opioids

 (5) Vitamin D3 (through its action on LL37)

 (6) Lansoprazole (through its action on SOCS1)

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