Antidepressant Effects on Insulin Sensitivity and Proinflammatory Cytokines in the Depressed Males

Table 1

Differences of body weight, depressive symptoms, and metabolic parameters of glucose metabolism in depressed patients before and after treatment.

	Before	After
	($N=43$, mean $\pm$ SE)	($N=43$, mean ± SE)
Age (years)	23.3 ± 0.4	22.3 ± 0.4
Body weight (kg)	65.7 ± 1.0	65.8 ± 1.1
BMI (kg/m^2)	22.6 ± 0.3	22.1 ± 0.3
Systolic BP (mmHg)	119.6 ± 1.6	117.9 ± 1.4
Diastolic BP (mmHg)	76.8 ± 1.2	75.3 ± 0.9
HAM-D	31.1 ± 1.5	16.5 ± 1.7**
HOMA-IR	1.11 ± 0.14	1.25 ± 0.15
HOMA-$\beta$	154.74 ± 56.20	273.09 ± 92.30
$\mathrm{\Delta }$I/$\mathrm{\Delta }$G ($\mu$IU/mg)	144.2 ± 13.8	149.9 ± 17.4
${\text{S}}_{\text{I}}$ (10^−5 min^−1/pmol)	0.90 ± 0.09	0.70 ± 0.08
${\text{S}}_{\text{G}}$ (min^−1)	0.028 ± 0.003	0.035 ± 0.007
AIR (pmol)	3440 ± 424	4100 ± 419
DI (${\text{S}}_{\text{I}}$  $\times$ AIR)	2871 ± 400	2968 ± 407

* $P<.05$
** $P<.005$.