Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat)

Table 1

Body weight, lipid profile and blood pressure in the control and diabetic ZDF rats at the initial and final time (6 weeks of vehicle or sitagliptin treatment).

	Initial Time (20 wks)		Final Time (26 wks)
	Control ZDF ($+/+$)	Diabetic ZDF (fa/fa)	Control ZDF (+/+)	Diabetic ZDF (fa/fa)
Groups	($n=16$)	($n=16$)	Vehicle ($n=8$)	Vehicle ($n=8$)	Sitagliptin ($n=8$)
BW (g)	$406.70\pm 6.83$	$388.10\pm 8.87$	$445.70\pm 8.16$	$354.40\pm {8.85}^{\text{aaa}}$	380.00$\pm$14.46
Total-c (mg/dl)	$77.50\pm 1.50$	$155.50\pm {3.50}^{\text{aaa}}$	$93.00\pm 2.96$	$193.00\pm {9.79}^{\text{aaa}}$	193.10$\pm$4.62
TGs (mg/dl)	$115.00\pm 11.00$	$374.50\pm {4.95}^{\text{a}}$	$154.00\pm 19.14$	$400.20\pm {27.00}^{\text{aaa}}$	$237.10\pm {22.54}^{\text{bbb}}$
Systolic (mmHg)	$115.50\pm 0.83$	$125.20\pm 0.27$	$116.00\pm 2.52$	$127.80\pm {1.23}^{\text{a}}$	$101.60\pm {0.78}^{\text{bbb}}$
Diastolic (mmHg)	$100.98\pm 0.82$	$91.46\pm 0.83$	$103.50\pm 1.94$	$112.70\pm 3.98$	$94.86\pm {0.70}^{\text{bbb}}$
Mean (mmHg)	$104.25\pm 0.25$	$108.20\pm 1.42$	$104.30\pm 4.25$	$117.40\pm {3.04}^{\text{a}}$	$96.86\pm {0.51}^{\text{bbb}}$
Pulse P (mmHg)	$14.52\pm 0.98$	$33.74\pm 0.37$	$14.00\pm 4.16$	$15.09\pm 3.08$	$6.71\pm {1.11}^{\text{b}}$

BW, body weight; P, pressure; SITA, sitagliptin; Total-c, Total-cholesterol; TGs, triglycerides; ZDF, Zucker diabetic fatty. Values are means $\pm$ SEM of $n$ rats. Comparisons between groups: a - ZDF (fa/fa) versus ZDF ($+/+$) and b - sitagliptin versus vehicle; $P<.05\text{,}$$P<.01$ and $P<.001$ for one, two or three letters, respectively.