Both IL-1β and TNF-α Regulate  NGAL Expression in Polymorphonuclear Granulocytes of  Chronic Hemodialysis Patients

<table>Role of TNF-<i>α</i> on the kinetics of NGAL production by PMG from preHDF and postHDF patients and HS. <sup>+</sup>Significantly different (<svg height="10.1" id="M67" style="vertical-align:-0.27pt" version="1.1" viewbox="0 0 43.337502 10.1" width="43.337502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.1)">
<g transform="translate(72,-63.92)">
<text transform="matrix(1,0,0,-1,-71.95,64.24)">
<tspan style="font-size: 11.21px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 11.21px; " x="9.7621679" y="0">&lt;</tspan>
<tspan style="font-size: 11.21px; " x="20.555471" y="0">.</tspan>
<tspan style="font-size: 11.21px; " x="23.357471" y="0">0</tspan>
<tspan style="font-size: 11.21px; " x="28.961472" y="0">5</tspan>
</text>
</g>
</g>
</svg>) from that of LPS-stimulated PMG. *Significantly different (<svg height="10.1" id="M68" style="vertical-align:-0.27pt" version="1.1" viewbox="0 0 43.337502 10.1" width="43.337502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.1)">
<g transform="translate(72,-63.92)">
<text transform="matrix(1,0,0,-1,-71.95,64.24)">
<tspan style="font-size: 11.21px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 11.21px; " x="9.7621679" y="0">&lt;</tspan>
<tspan style="font-size: 11.21px; " x="20.555471" y="0">.</tspan>
<tspan style="font-size: 11.21px; " x="23.357471" y="0">0</tspan>
<tspan style="font-size: 11.21px; " x="28.961472" y="0">5</tspan>
</text>
</g>
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</svg>) from that of rhTNF-alpha-treated PMG. °Significantly different (<svg height="10.1" id="M69" style="vertical-align:-0.27pt" version="1.1" viewbox="0 0 43.337502 10.1" width="43.337502" xmlns="http://www.w3.org/2000/svg">
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<g transform="translate(72,-63.92)">
<text transform="matrix(1,0,0,-1,-71.95,64.24)">
<tspan style="font-size: 11.21px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 11.21px; " x="9.7621679" y="0">&lt;</tspan>
<tspan style="font-size: 11.21px; " x="20.555471" y="0">.</tspan>
<tspan style="font-size: 11.21px; " x="23.357471" y="0">0</tspan>
<tspan style="font-size: 11.21px; " x="28.961472" y="0">5</tspan>
</text>
</g>
</g>
</svg>) from that of unstimulated PMG. <sup>•</sup>Significantly different (<svg height="10.1" id="M70" style="vertical-align:-0.27pt" version="1.1" viewbox="0 0 43.337502 10.1" width="43.337502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.1)">
<g transform="translate(72,-63.92)">
<text transform="matrix(1,0,0,-1,-71.95,64.24)">
<tspan style="font-size: 11.21px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 11.21px; " x="9.7621679" y="0">&lt;</tspan>
<tspan style="font-size: 11.21px; " x="20.555471" y="0">.</tspan>
<tspan style="font-size: 11.21px; " x="23.357471" y="0">0</tspan>
<tspan style="font-size: 11.21px; " x="28.961472" y="0">5</tspan>
</text>
</g>
</g>
</svg>) from that of rhTNF-alpha-treated PMG.</table>

Mediators of Inflammation

fig2

Figure 2

Figure 2: Both IL-1β and TNF-α Regulate  NGAL Expression in Polymorphonuclear Granulocytes of  Chronic Hemodialysis Patients 