Clinical Study

Both IL-1β and TNF-α Regulate NGAL Expression in Polymorphonuclear Granulocytes of Chronic Hemodialysis Patients

Table 1

Main characteristics of the study cohort.

ParameterHDF patients ( 𝑛 3 0 ) HSS ( 𝑛 1 8 )

Gender (M/F)16/1410/8
Age (yrs) 5 5 ± 1 2 5 6 ± 9
Dialysis vintage (mos)38 [8–299]
spKt/V (weekly mean) 1 . 2 1 ± 0 . 1 9
PCR (g/Kg/day) 1 . 1 8 ± 0 . 2 3
PTH (pg/mL)188 [42–348]
Creatinine (mg/dL) 9 . 9 ± 2 . 1 0 . 9 ± 0 . 2
Urea (mg/dL) 1 7 7 . 4 ± 3 9 . 6 1 8 . 5 ± 3 . 3
Ca X P product (mg2/dL2) 4 6 . 6 ± 1 3 . 3 3 0 . 1 ± 1 . 9
Hemoglobin (g/dL) 1 1 . 6 ± 1 . 8 1 5 . 0 ± 2 . 0
Hematocrit (%) 3 1 . 9 ± 3 . 0 4 4 . 3 ± 3 . 7
Erythrocytes ( 𝑛 × 1 0 6 ) 3 . 5 9 ± 0 . 9 8 4 . 9 3 ± 0 . 8 1
White Cells ( 𝑛 × 1 0 6 ) 6 . 5 ± 1 . 6 7 . 8 ± 1 . 1
Albumin (g/dL) 4 . 2 2 ± 0 . 6 5 4 . 0 6 ± 0 . 4 3
hsCRP (mg/L)6 [1–42]0.15 [0.07–0.44]
β2-microglobulin (mg/dL)29 [7–53] 0 . 1 2 ± 0 . 4
Uric acid (mg/dL) 6 . 0 2 ± 1 . 0 8 5 . 0 3 ± 0 . 7 7
Serum iron (mcg/mL) 5 9 . 9 ± 1 9 . 8 8 8 . 5 ± 1 8 . 1
Serum transferrin (mg/dL) 1 8 7 . 1 ± 4 5 . 0 3 0 0 . 9 ± 3 7 . 1
Serum ferritin (ng/mL)155 [9–789]151 ± 33