Clinical Study

Both IL-1β and TNF-α Regulate NGAL Expression in Polymorphonuclear Granulocytes of Chronic Hemodialysis Patients

Table 2

Kinetics of IL-1β (pg/mL) and TNF-α (pg/mL) release by PMG from preHDF and postHDF patients and HS.

IL-1β   (pg/ml)TNF-α   (pg/ml)
18 h24 h48 h18 h24 h48 h

preHDF
 none<1<1<1<1.6<1.6<1.6
 LPS 7 0 . 1 ± 8 . 3 1 2 0 . 2 ± 1 5 . 4 3 2 . 7 ± 7 . 9 8 5 . 4 ± 1 5 . 3 1 2 3 . 7 ± 2 1 . 9 5 1 . 6 ± 2 0 . 9

postHDF
 none<1<1<1<1.6<1.6<1.6
 LPS 4 0 7 . 5 ± 3 7 . 4 ** 5 1 1 . 8 ± 6 8 . 6 ** 3 3 1 . 3 ± 2 1 . 7 ** 2 8 6 . 2 ± 8 7 . 1 ** 4 8 1 . 4 ± 9 8 . 3 ** 1 9 2 . 5 ± 6 1 . 8 **

HS
 none<1<1<1<1.6<1.6<1.6
 LPS 7 9 7 . 5 ± 6 5 . 8 * 8 1 0 . 7 ± 5 8 . 5 * 5 5 0 . 3 ± 3 9 . 8 * 1 4 0 9 . 3 ± 9 9 . 1 * 1 8 4 7 . 3 ± 1 2 1 . 7 * 1 0 5 5 . 4 ± 1 1 1 . 6 *

*Significantly different ( 𝑃 < . 0 5 ) compared with those obtained from pre and postHD.
**Significantly different ( 𝑃 < . 0 5 ) compared with those obtained from preHD.