The p110𝛼 and p110𝛽 Isoforms of Class I Phosphatidylinositol 3-Kinase Are Involved in Toll-Like Receptor 5 Signaling in Epithelial Cells

Table 1

Activities of pharmacologic inhibitors used in this study (IC₅₀ in nM).

Enzyme	LY294002	LY303511	GDC0941	PI-103	TGX-221	PIK-93
p110$\alpha$	500	$>$1000	3	8	$>$1000	39
p110$\beta$	300–973	$>$1000	33	88–340	7–8.5	590
p110$\gamma$	1000–7000	$>$1000	75	15	$>$1000	16
p110$\delta$	570–1300	$>$1000	3	48->500	$>$100	120
mTor	Active	?	580	20	?	1380
other	CK2	?	Class II PI3K (0.67)			PI4KIIIb

Data compiled from [24–28].