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Mediators of Inflammation
Volume 2010 (2010), Article ID 823821, 27 pages
http://dx.doi.org/10.1155/2010/823821
Review Article

Regulation of I 𝜅 B 𝛼 Function and NF- 𝜅 B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages

1Department of Biology and Chemistry, Faculty of Arts and Sciences, American University of Sharjah, P.O. Box 26666, Sharjah, UAE
2Department of Biochemistry and Molecular Biology, Faculty of Medicine, Sir Charles Tupper Medical Building, Dalhousie University, Halifax, NS, B3H 1X5, Canada

Received 17 November 2009; Accepted 12 January 2010

Academic Editor: Hidde Bult

Copyright © 2010 Amin Majdalawieh and Hyo-Sung Ro. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

NF- 𝜅 B comprises a family of transcription factors that are critically involved in various inflammatory processes. In this paper, the role of NF- 𝜅 B in inflammation and atherosclerosis and the regulation of the NF- 𝜅 B signaling pathway are summarized. The structure, function, and regulation of the NF- 𝜅 B inhibitors, I 𝜅 B 𝛼 and I 𝜅 B 𝛽 , are reviewed. The regulation of NF- 𝜅 B activity by glucocorticoid receptor (GR) signaling and I 𝜅 B 𝛼 sumoylation is also discussed. This paper focuses on the recently reported regulatory function that adipocyte enhancer-binding protein 1 (AEBP1) exerts on NF- 𝜅 B transcriptional activity in macrophages, in which AEBP1 manifests itself as a potent modulator of NF- 𝜅 B via physical interaction with I 𝜅 B 𝛼 and a critical mediator of inflammation. Finally, we summarize the regulatory roles that recently identified I 𝜅 B 𝛼 -interacting proteins play in NF- 𝜅 B signaling. Based on its proinflammatory roles in macrophages, AEBP1 is anticipated to serve as a therapeutic target towards the treatment of various inflammatory conditions and disorders.