Distribution of Major Basic Protein on Human Airway following In Vitro Eosinophil Incubation

Figure 4

Representative image showing distribution of immunoreactive MBP and smooth muscle actin within 2 mm human airway following overnight incubation with human eosinophils. Immunoreactive actin (green) and MBP (red) are shown. Two patterns of extracellular MBP deposition are noted broad linear deposition along luminal and abluminal surfaces, and (arrows) discrete focal deposition within the airway media, especially in the vicinity of airway myocytes (confocal microscopy 400x).