The Effect of Chronic Candesartan Therapy on the Metabolic Profile and Renal Tissue Cytokine Levels in the Obese Zucker Rat
Renal cortical pathology: glomerulosclerosis and tubulointerstitial fibrosis were assessed in periodic acid Schiff and Masson’s trichrome-stained paraffin sections (4 m sections, 6 sections/kidney were analyzed) from Zucker rats (Lean or obese) treated with (+CAN) or without candesartan (−CAN) (/bodytype/treatment). (a) Masson trichrome-stained paraffin sections showing enlarged lumens of the renal tubules and heavy deposition of collagen in the interstitial spaces (light-blue staining, arrows) in untreated rats only. (b) Periodic acid Schiff’s-stained paraffin sections. The mesangial expansion is shown by arrows and hyaline casts by (c) in the renal tubules in untreated rats only.