Lipid Mediators in Acne

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td align="center" colspan="2">Squalene peroxidation</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">Harmful effects</td><td align="left">Acne sebum</td></tr><tr><td align="center" colspan="2"><hr/></td></tr><tr><td align="left">Comedogenicity</td><td align="left" rowspan="7">Increased amount of squalene peroxidation products accompanied by decreased level of vitamin E</td></tr><tr><td align="left">Sebaceous gland</td></tr><tr><td align="left">
									hyperplasia</td></tr><tr><td align="left">Hyperkeratosis</td></tr><tr><td align="left">Release of inflammatory</td></tr><tr><td align="left">
									 mediators from</td></tr><tr><td align="left">
									keratinocytes</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<i>Harmful effects of squalene peroxidation</i>. The adverse effects of squalene peroxidation products and in particular of squalene monohydroperoxide have been assessed both in vitro and in vivo. Moreover, sebum from acne patients seems to have high level of squalene peroxide.

Mediators of Inflammation

Lipid Mediators in Acne

Table 2