Table 2: Harmful effects of squalene peroxidation. The adverse effects of squalene peroxidation products and in particular of squalene monohydroperoxide have been assessed both in vitro and in vivo. Moreover, sebum from acne patients seems to have high level of squalene peroxide.

Squalene peroxidation

Harmful effectsAcne sebum

ComedogenicityIncreased amount of squalene peroxidation products accompanied by decreased level of vitamin E
Sebaceous gland
hyperplasia
Hyperkeratosis
Release of inflammatory
mediators from
keratinocytes