Apocynin Improves Insulin Resistance through Suppressing Inflammation in High-Fat Diet-Induced Obese Mice
Figure 1
Effect of apocynin on body weight, food intake, and energy intake. C57BL/6 mice were fed with HFD for 12 weeks to induce insulin resistance. After 12 weeks of feeding, the HFD-fed mice were divided into two groups. The HFD-fed mice in one group were treated with apocynin (2.4 g/L) in drink water (HFD-Apo, ) for another 5 weeks HFD feeding; the HFD-fed mice in the other group were employed as HFD controls (HFD-Con, ). Normal control mice were fed a normal diet and untreated with apocynin (ND-Con, ). (a) Body weight of three groups. The body weight of the HFD-Apo group was lower than that of the HFD-Con group since the fourth week after apocynin treatment. (b) Food intake. The food intake of the HFD-Apo group and HFD-Con group were lower than that in the ND-Con group. (c) Energy intake. There are no differences among groups. #versus ND-Con group, * versus HFD-Con group.
