Elevated Adiponectin Serum Levels in Women with Systemic Autoimmune Diseases
Table 1
Demographics, body composition and distribution, serum adipokines and ghrelin levels in women with systemic autoimmune disease, in patients with Sjögren syndrome and healthy women (results are given as mean ± SEM; : Man Whitney test between patients with systemic autoimmune disease and healthy controls; : Man Whitney test between patients with Sjögren’s syndrome and healthy controls).
Systemic autoimmune diseases whole series (N = 15)
Sjögren syndrome (N = 7)
Healthy controls (N = 15)
Age (years)
57.7 ± 3.5
59.5 ± 3.7
54.5 ± 2.1
NS
NS
Disease duration (years)
6.5 ± 1.4
4.7 ± 1.1
—
—
—
Clinical manifestations
Polyarthritis/ arthralgia: N = 14 Myalgia N = 2 Dermatological manifestations N = 2 Sicca syndrome N =7 Peripheral neuropathy N = 1Pulmonary involvement N = 2 Raynaud syndrome N = 3 Renal disease N = 0
—
—
—
—
BMI (kg/m2)
29.0 ± 1.9
32.03 ± 3.5
25.4 ± 1.1
NS
NS
Corticosteroid dosage (mg/day)
6.6 ± 1.3
5.7 ± 2.2
—
—
—
Cumulative corticosteroid dose (mg)
11018 ± 4481
9192.8 ± 5349
—
—
—
ESR (mm/H)
16.3 ± 2.6
17.8 ± 4.6
14.5 ± 5.3
NS
NS
CRP (mg/L)
6.5 ± 1.9
5 ± 2
5.7 ± 1.8
NS
NS
IL-6 (pg/mL)
9.02 ±3.69
6.7 ± 3.2
0.02 ± 0.02
.025
.05
Glycemia (mmol/L)
4.8 ± 0.1
4.9 ± 0.2
4.6 ± 0.1
NS
NS
Insulin (μIU/L)
10.3 ± 2.05
12.8 ± 3.9
8.6 ± 1.1
NS
NS
HOMA-IR
2.14 ± 0.37
2.6 ± 0.6
1.49 ± 0.15
NS
NS
Total cholesterol (g/L)
1.88 ± 0.1
1.9 ± 0.2
1.83 ± 0.1
NS
NS
LDL cholesterol (g/L)
1.02 ± 0.1
1.05 ± 0.2
1.03 ± 0.1
NS
NS
HDL cholesterol (g/L)
0.61 ± 0.04
0.7 ± 0.05
0.57 ± 0.04
NS
NS
Leptin (ng/mL)
25.2 ± 5.6
31.1 ± 10.6
14.4 ± 3.4
NS
NS
Leptin /fat mass (ng/mL/Kg)
0.72 ± 0.1
0.7 ± 0.2
0.82 ± 0.1
NS
NS
Adiponectin (μg/mL)
16.3 ± 1.6
17.8 ± 2.6
9.7 ± 0.6
.01
.04
Ghrelin (pg/mL)
1118 ± 127
1249. 1 ± 220.5
1012 ± 56
NS
NS
Fat mass (g)
30140 ± 3411
33554.1 ± 5573.1
21518 ± 1862
NS
NS
Lean mass (g)
40822 ± 1348
42475.7 ± 2128.5
47011 ± 1908
NS
NS
Adiposity (%)
40.9 ± 2.3
42.8 ± 2.8
30.8 ± 1.8
NS
NS
Fat in the android region (g)
2681 ± 421
3099 ± 741.1
1951 ± 222
NS
NS
Fat in the gynoid region (g)
5710 ± 541
6282.9 ± 794.2
3905 ± 340
NS
NS
(ESR: erythrocyte sedimentation rate; BMI: body mass index; HOMA-IR: homeostasis model assessment index; NS: nonsignificant).
