Normal Human Gingival Epithelial Cells Sense C. parapsilosis by Toll-Like Receptors and Module Its Pathogenesis through Antimicrobial Peptides and Proinflammatory Cytokines

Figure 4

Effect of C. parapsilosis on tissue structure and the formation of a biofilm on the engineered human oral mucosa. Histological features of EHOM following exposure to C. parapsilosis. EHOM tissue was infected with (a) no Candida cells (uninfected control) and (b, c) C. parapsilosis strain. Note the formation of a biofilm on the tissue (b) and the presence of C. parapsilosis in the connective tissue (c). Representative photographs of four different experiments are shown (two EHOMs per experiment). Magnification $\times$250 for parts (a) and (b), and $\times$600 for part (c). e: epithelium.

(a)

(b)

(c)