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Mediators of Inflammation
Volume 2010, Article ID 951210, 7 pages
http://dx.doi.org/10.1155/2010/951210
Research Article

Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice

1Key Laboratory of Anti-inflammatory and immunopharmacology in Education Ministry of China, Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, China
2Jiangsu Provincial Key Laboratory of Pharmacology and Safety Evaluation of Material Medica, Department of pharmacology, Nanjing University of Traditional Chinese Medicine, No. 282 Hanzhong Road, Nanjing 210029, China
3Institute for Biomedical Electronic Engineering, Nanjing University, Nanjing 210093, China

Received 11 January 2010; Revised 9 May 2010; Accepted 21 June 2010

Academic Editor: Yvette Mandi

Copyright © 2010 Ling-ling Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Systemic lupus erythematosus (SLE) develops in relation to many environmental factors. In our opinion, it is more important to investigate the effect of melatonin on the environmental- related SLE. In the present study, 0.5 ml pristane were used to induce SLE in female BALB/c mice. Melatonin (0.01, 0.1, 1.0 mg/kg) was orally administered immediately after pristane-injection for 24 weeks. IgM anti ssDNA and histone antibodies were detected after 0, 1, 2, 4, 8 weeks pristane injection. The levels of IL-2, IL-6 and IL-13 were detected after 24 weeks. Renal lesions were also observed. The results showed that melatonin antagonized the increasing levels of IgM anti ssDNA and histone autoantibodies. Melatonin could also decrease the IL-6 and IL-13 production and increase the IL-2 production. Besides, melatonin could lessen the renal lesions caused by pristane. These results suggested that melatonin has a beneficial effect on pristane-induced lupus through regulating the cytokines disturbances.