Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice

Table 1

Renal histopathological features of the mice in different groups ($n=6\text{–}8$). The degree of severity of histological lesions was evaluated as absent ($-$), mild ($+$), moderate ($++$), and severe ($+++$).

Group	Glomerulonephritis			Renal tubular lesions			Interstitial inflammation
	Atrophy	Capillary walls thickening	Mesangial broadening	Dilation	Epithelial cells proliferation	Protein casts	Inflammatory cells infiltration	Fibroblasts proliferation
Normal	$-$	$-$	$-$	$-$	$-$	$-$	$-$	$-$
Model	$++$	$++$	$++$/$+++$	$++$	$++$/$+++$	$++$	$++$/$+++$	$++$
Pre	$+$	$+$	$+$	$+$/$++$	$+$/$++$	$-~++$	$+$	$-$
MT1	$++$	$++$	$++$	$++$	$++$	$+$	$++$	$++$
MT2	$++$	$+$	$+$	$+$	$+$	$-~++$	$+$	$-$
MT3	$+$	$-$/$+$	$+$	$-$/$+$	$-$/$+$	$-$/$+$	$+$	$-$