Redox Responses in Patients with Sepsis: High Correlation of Thioredoxin-1 and Macrophage Migration Inhibitory Factor Plasma Levels

Table 2

Comparison of IL-6, TRX1, and MIF plasma levels, as well as APACHE II, SAPS II, and SOFA scores in survivors and nonsurvivors in the septic group at baseline and at 24 and 48 hours.

		Survivor ($n=8$)	Nonsurvivor ($n=7$)	$P$-value
IL-6 (pg/ml)	$t0$	578.7; 451.4–579.9	576.1; 521.9–581.6	$>$.05
	$t24$	262.2; 103.4–300.3	371.2; 153.6–553.7	$>$.05
	$t48$	53.0; 41.0–79.6	51.7; 47.4–312.0	$>$.05
$P$-value	$t0$-$t24$-$t48$	$>$.05	$>$.05
TRX1 (ng/ml)	$t0$	26.8; 14.2–44.7	57.5; 22.0–82.2	$>$.05
	$t24$	25.8; 13.4–47.8	22.9; 16.3–28.0	$>$.05
	$t48$	12.9; 9.5–16.1	23.8; 21.1–27.9	$>$.05
$P$-value	$t0$-$t24$-$t48$	$>$.05	$>$.05
MIF (pg/ml)	$t0$	1645.8; 345.1–4078.7	1821.1; 971.9–3147.6	$>$.05
	$t24$	624.7; 396.3–1899.5	889.0; 432.4–1467.3	$>$.05
	$t48$	421.8; 315.3–692.7	951.1; 425.8–1469.0	$>$.05
$P$-value	$t0$-$t24$-$t48$	$>$.05	.05*
APACHE II (points)	$t0$	43.0; 35.0–45.0	33.0; 32.5–37.0	$>$.05
	$t24$	35.0; 29.5–40.8	43.0; 38.8–45.0	$>$.05
	$t48$	34.0; 23.5–38.5	35.0; 35.0–36.0	$>$.05
$P$-value	$t0$-$t24$-$t48$	$>$.05	$>$.05
SOFA (points)	$t0$	13.0; 11.0–15.0	16.5; 15.0–18.0	$>$.05
	$t24$	13.0: 11.5–15.5	16.5; 14.3–18.0	$>$.05
	$t48$	14.0: 12.0–15.0	18.0; 9.0–18.0	$>$.05
$P$-value	$t0$-$t24$-$t48$	$>$.05	$>$.05
SAPS II (points)	$t0$	60.5; 54.8–66.3	81.0; 72.3–89.3	$>$.05
	$t24$	73.0; 60.0–77.0	76.5; 66.0–84.5	$>$.05
	$t48$	63.0; 57.5–75.5	76.0; 71.0–90.0	$>$.05
$P$-value	$t0$-$t24$-$t48$	$>$.05	$>$.05

Data are presented by median and interquartile range (Q1–Q3).