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Mediators of Inflammation
Volume 2011, Article ID 152137, 4 pages
http://dx.doi.org/10.1155/2011/152137
Research Article

Effect of ω-3 Fatty Acid on Gastrointestinal Motility after Abdominal Operation in Rats

1Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, No. 1 Shuaifuyuan Wangfujing, Beijing 100730, China
2Department of Pathophysiology, Peking Union Medical College, No. 1 Shuaifuyuan Wangfujing, Beijing 100730, China

Received 12 October 2010; Revised 20 December 2010; Accepted 19 January 2011

Academic Editor: Chiara de Luca

Copyright © 2011 Qun Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To investigate whether ω-3 fatty acid could stimulate gastrointestinal motility after abdominal operation. Method. Wistar rats were randomly divided into 3 group (normal saline group, intralipid group, and ω-3 fatty acid group, /group) after partial caecectomy and gastrostomosis, each group was divided into 3 groups (POD1, POD3, and POD6, /group). Serum gastrin (GAS), motilin (MTL), interleukin-1 (IL-1), interleukin-6 (IL-6), tissue necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2), gastric emptying rate, and small bowel propulsion rate were measured. Results. On POD 3, gastric emptying rate and small bowel propulsion rate in ω-3 fatty acid group were higher than those in normal saline group and intralipid group. Serum GAS and MTL levels in ω-3 fatty acid group were higher than those in normal saline group, but serum IL-1, IL-6, TNF-α, and COX-2 levels were lower than those in normal saline group and intralipid group. Conclusion. ω-3 fatty acid could accelerate the recovery of gastrointestinal mobility after abdominal operation in rats, mainly by relieving postoperative inflammation.