Mediators of Inflammation

Clinical Study

Phosphodiesterase Type 4D Gene Polymorphism: Association with the Response to Short-Acting Bronchodilators in Paediatric Asthma Patients

Table 3

FEV₁% change following administration of albuterol according to PDE4D genotypes.


SNP/genotypes		% FEV₁ change (mean ± SE)**	P ***

rs1544791 intron 2
AA	8	13.7 (±2.1)	0.01
AG	34	6.6 (±1.0)
GG	51	7.9 (±0.8)
GG + GA versus AA		7.4 ± 0.7 versus 13.7 ± 2.1	0.006

*rs1504982 (−1345)**
CC	22	7.0 (±1.3)	0.08
CT	46	7.1 (±0.9)
TT	25	10.3 (±1.2)
CC + CT versus TT		7.1 ± 0.7 versus 10.3 ± 1.2	0.03

*rs10940648 (−984)**
CC	6	8.2 (±2.6)	0.4
TC	28	6.6 (±1.2)
TT	59	8.5 (±0.8)

rs829259
AA	13	8.5 (±1.7)	0.1
AT	45	6.6 (±0.9)
TT	35	9.5 (±1.1)

rs1544791 is located in intron 2 of PDE4D7 isoform; *positions of rs1504982 and rs10940648 refer to the start of PDE4D5 mRNA (AF012073), and rs829259 is located in 3′UTR common to all splice variants; **mean values adjusted for baseline FEV₁; ***P derived from ANCOVA.