Mediators of Inflammation

Research Article

Evaluation of Plaque Stability of Advanced Atherosclerotic Lesions in Apo E-Deficient Mice after Treatment with the Oral Factor Xa Inhibitor Rivaroxaban

Figure 1

Morphometric analysis data. Administration of rivaroxaban in the chow diet over 26 weeks did not significantly reduce maximum lesion area (a), percentage of stenosis (b), lesion thickness (c), necrotic core area (e), or percentage of the necrotic core area in relation to total lesion area (f). Thickness of the protective fibrous cap was significantly larger in mice, receiving the high-concentration rivaroxaban, as compared to control mice ((d), ). Data represent mean ± SEM. * .
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(a)
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(b)
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(c)
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(d)
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(e)
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(f)