Evaluation of Plaque Stability of Advanced Atherosclerotic Lesions in Apo E-Deficient Mice after Treatment with the Oral Factor Xa Inhibitor Rivaroxaban
Figure 2
Immunohistochemistry. Immunohistochemistry staining with antibodies against Mac-2 (a, c), demonstrating presence of macrophages within an advanced lesion. Mac-2 was predominantely located within the necrotic cores (arrows) and did not significantly differ between the three experimental groups. Staining for alpha actin (b, d) was predominantely located within the fibrous cap (arrows) and showed a trend reduction () in the high-concentration group, as compared to the control group. Both representative cross-sections (c, d) were from mice that received high-concentration of rivaroxaban (5 mg/kg/day). Error bars represent mean ± SEM.
