Mediators of Inflammation

Research Article

Evaluation of Plaque Stability of Advanced Atherosclerotic Lesions in Apo E-Deficient Mice after Treatment with the Oral Factor Xa Inhibitor Rivaroxaban

Figure 3

RT-PCR of inflammatory mediators. Chronic administration of both concentrations of rivaroxaban significantly decreased mRNA expression of MCP-1 (b), IL-6 (c), TNF-α (d), and Egr-1 (f) in aortic tissue of rivaroxaban-treated mice, as compared to the control group. Mice receiving the low (1 mg/kg/day), but not the high dose (5 mg/kg/day) of rivaroxaban, showed a significant reduction of mRNA expression of IFN-γ (e). There were no significant differences in respect of tissue factor expression between the three groups (a). Data represent fold increase of mRNA expression as compared to the control group. Data represent mean ± SEM. * .
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