Evaluation of Plaque Stability of Advanced Atherosclerotic Lesions in Apo E-Deficient Mice after Treatment with the Oral Factor Xa Inhibitor Rivaroxaban

Table 2

Morphologic lesion analysis A. Brachiocephalica.

	Control	Low	High	𝑃
	(𝑛=19)	(𝑛=20)	(𝑛=20)
Thin fibrous cap	16/19	17/20	17/20	ns
Large necrotic core	11/19	13/20	11/20	ns
Medial erosion	15/19	12/20	9/20	^∗𝑃<.05
Calcification	12/19	13/20	12/20	ns
Cholesterol crystals	19/19	19/20	20/20	ns
Lateral xanthoma	7/19	3/20	1/20	^∗𝑃<.05
Hemorrhage	11/19	7/20	6/20	ns

*high concentration versus control group.