Lower Frequency of CD62L^high and Higher Frequency of TNFR2⁺ Tregs Are Associated with Inflammatory Conditions in Type 1 Diabetic Patients

Figure 2

Expression of CD62L and TNFR2 defined as mean fluorescence intensity in diabetic type 1 patients and healthy individuals. During cytometric analysis of peripheral blood CD4⁺CD25^high T cells, the mean fluorescent intensity of CD62L and TNFR2 was defined. The MFI of CD62L in CD4⁺CD25^highCD62L^high gate in diabetic group was 22.34 (15.91/26.6) and 37.7 (29.8/57.5) in control group (𝑃=.0001). The MFI of TNFR2 in CD4⁺CD25^highTNFR2⁺ gate was 5.66 (4.52/7.83) in DM1 group and 3.96 (2.32/5.37) in the control group (𝑃=.0004). The data are presented as median and 10th percentile/90th percentile. The differences were calculated by 𝑈-Mann Whitney test.

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