Lower Frequency of CD62L^high and Higher Frequency of TNFR2⁺ Tregs Are Associated with Inflammatory Conditions in Type 1 Diabetic Patients

Figure 4

Relationship between CD4⁺CD25^high regulatory T cells, their subpopulations frequencies, and CRP level in analyzed DM1 subjects. The level of C-reactive protein was measured in the blood of DM1 children and correlated with the percentage of peripheral blood regulatory T-cell subpopulations. The Spearman test was used to calculate the strength of correlation. (a) The correlation between CD4⁺CD25^high frequency and CRP level in DM1 subjects (𝑟=[−0.69]); (b) the correlation between CD4⁺CD25^highCD62L^high frequency and CRP level in DM1 subjects (𝑟=[−0.64]); (c) the correlation between CD4⁺CD25^highTNFR2⁺ frequency and CRP level in DM1 subjects (𝑟=0.36). *The percentage of cells among peripheral blood lymphocytes, **the percentage of cells among CD4⁺CD25^high lymphocytes.

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(b)

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