Nuclear Factor-Kappa B Activity Regulates Brain Expression of P-Glycoprotein in the Kainic Acid-Induced Seizure Rats
Figure 4
Pretreatment of PDTC and DEX both decreases KA induced P-gp overexpression. P-gp expression was detected by immunohistochemistry staining (×400) with an anti-P-gp antibody. A few P-gp positive cells were observed in the control NS group (NS). The number of the P-gp immunoreactive cells significantly increased in the KA micro-injected brain of EP group (EP), and it was mainly in vascular endothelial cells. By contrast with EP group, P-pg immunoreactive cells were decreased similarly in KA micro-injected brains pre-treated with PDTC (PDTC) or DEX (DEX). ↓: Neurons; ←: glial cells; →: vascular endothelial cells.
