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Mediators of Inflammation
Volume 2011, Article ID 703031, 7 pages
http://dx.doi.org/10.1155/2011/703031
Research Article

Apelin Serum Level in Egyptian Patients with Chronic Hepatitis C

1Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt
2Tropical Medicine Department, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt

Received 8 May 2011; Revised 8 July 2011; Accepted 25 August 2011

Academic Editor: Giamila Fantuzzi

Copyright © 2011 Hala O. El-Mesallamy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. Tatemoto, M. Hosoya, Y. Habata et al., “Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor,” Biochemical and Biophysical Research Communications, vol. 251, no. 2, pp. 471–476, 1998. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Rafael, “Hypothalamic ischemia and metabolic syndrome. Comment to: apelin and visfatin: unique “beneficial” adipokines upregulated in obesity?” Medical Science Monitor, vol. 12, no. 9, pp. RA112–RA119, 2006. View at Google Scholar · View at Scopus
  3. A. Kasai, N. Shintani, M. Oda et al., “Apelin is a novel angiogenic factor in retinal endothelial cells,” Biochemical and Biophysical Research Communications, vol. 325, no. 2, pp. 395–400, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. B. Masri, N. Morin, M. Cornu, B. Knibiehler, and Y. Audigier, “Apelin (65-77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells,” FASEB Journal, vol. 18, no. 15, pp. 1909–1911, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Ishida, T. Hashimoto, Y. Hashimoto et al., “Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo,” Journal of Biological Chemistry, vol. 279, no. 25, pp. 26274–26279, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Tatemoto, K. Takayama, M. X. Zou et al., “The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism,” Regulatory Peptides, vol. 99, no. 2-3, pp. 87–92, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Boucher, B. Masri, D. Daviaud et al., “Apelin, a newly identified adipokine up-regulated by insulin and obesity,” Endocrinology, vol. 146, no. 4, pp. 1764–1771, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. D. Garica-Diaz, J. Campion, F. I. Milagro, and J. A. Martinez, “Adiposity dependent apelin gene expression: relationships with oxidative and inflammation markers,” Molecular and Cellular Biochemistry, vol. 305, pp. 87–94, 2007. View at Google Scholar
  9. G. T. Strickland, H. Elhefni, T. Salman et al., “Role of hepatitis C infection in chronic liver disease in Egypt,” American Journal of Tropical Medicine and Hygiene, vol. 67, no. 4, pp. 436–442, 2002. View at Google Scholar · View at Scopus
  10. P. Melgar-Lesmes, G. Casals, M. Pauta et al., “Apelin mediates the induction of profibrogenic genes in human hepatic stellate cells,” Endocrinology, vol. 151, no. 11, pp. 5306–5314, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Principe, P. Melgar-Lesmes, G. Fernández-Varo et al., “The hepatic apelin system: a new therapeutic target for liver disease,” Hepatology, vol. 48, no. 4, pp. 1193–1201, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Yokomori, M. Oda, K. Yoshimura, S. Machida, F. Kaneko, and T. Hibi, “Overexpression of apelin receptor (APJ/AGTRL1) on hepatic stellate cells and sinusoidal angiogenesis in human cirrhotic liver,” Journal of Gastroenterology, pp. 1–10, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Bertolani and F. Marra, “The role of adipokines in liver fibrosis,” Pathophysiology, vol. 15, no. 2, pp. 91–101, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Fainboim, A. Chernavsky, N. Paladino, A. C. Flores, and L. Arruvito, “Cytokines and chronic liver disease,” Cytokine & Growth Factor Reviews, vol. 18, no. 1-2, pp. 143–157, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. V. Ortiz, M. Berenguer, J. M. Rayon, D. Carrasco, and J. Berenguer, “Contribution of obesity to hepatitis C-related fibrosis progression,” The American Journal of Gastroenterology, vol. 97, no. 9, pp. 2408–2414, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Garcia-Monzon, O. Lo Iacono, R. Mayoral et al., “Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C,” Journal of Hepatology, vol. 54, no. 1, pp. 142–152, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. R. D'Souza, C. A. Sabin, and G. R. Foster, “Insulin resistance plays a significant role in liver fibrosis in chronic hepatitis C and in the response to antiviral therapy,” The American Journal of Gastroenterology, vol. 100, no. 7, pp. 1509–1515, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Moucari, T. Asselah, D. Cazals-Hatem et al., “Insulin resistance in chronic hepatitis C: association with genotypes 1 and 4, serum HCV RNA level, and liver fibrosis,” Gastroenterology, vol. 134, no. 2, pp. 416–423, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. J. M. Hui, A. Sud, G. C. Farrell et al., “Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression,” Gastroenterology, vol. 126, no. 2, p. 634, 2004. View at Google Scholar · View at Scopus
  20. L. Fartoux, A. Poujol-Robert, J. Guéchot, D. Wendum, R. Poupon, and L. Serfaty, “Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C,” Gut, vol. 54, no. 7, pp. 1003–1008, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Poynard, P. Bedossa, and P. Opolon, “Natural history of liver fibrosis progression in patients with chronic hepatitis C,” The Lancet, vol. 349, no. 9055, pp. 825–832, 1997. View at Publisher · View at Google Scholar · View at Scopus
  22. M. C. Bellizzi and W. H. Dietz, “Workshop on childhood obesity: summary of the discussion,” The American Journal of Clinical Nutrition, vol. 70, no. 1, pp. 173s–175s, 1999. View at Google Scholar · View at Scopus
  23. G. N. Ioannou, M. F. Splan, N. S. Weiss, G. B. McDonald, L. Beretta, and S. P. Lee, “Incidence and predictors of hepatocellular carcinoma in patients with cirrhosis,” Clinical Gastroenterology and Hepatology, vol. 5, no. 8, pp. 938–945, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. Y. Yilmaz and F. Eren. Reply to Aydin et al, “To what extent is it right to measure serum vaspin, obestatin, and apelin-36 levels without a protease inhibitor in nonalcoholic fatty liver disease?” Metabolism, vol. 60, p. e2, 2011. View at Google Scholar
  25. D. R. Matthews, J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher, and R. C. Turner, “Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man,” Diabetologia, vol. 28, pp. 412–419, 1985. View at Google Scholar
  26. C. Tiani, E. Garcia-Pras, M. Mejias et al., “Apelin signaling modulates splanchnic angiogenesis and portosystemic collateral vessel formation in rats with portal hypertension,” Journal of Hepatology, vol. 50, no. 2, pp. 296–305, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. B. Aktas, Y. Yilmaz, F. Eren et al., “Serum levels of vaspin, obestatin, and apelin-36 in patients with nonalcoholic fatty liver disease,” Metabolism-Clinical and Experimental, vol. 60, pp. 544–549, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. C. N. Ercin, T. Dogru, S. Tapan et al., “Plasma apelin levels are elevated in subjects with non-alcoholic fatty liver disease,” Journal of Hepatology, vol. 59, no. 7, pp. 977–981, 2009. View at Google Scholar
  29. G. Barnias, I. Zouboulis-Vafiadis, P. Nikolaou, S. I. Siakavellas, D. Perrea, and S. D. Ladas, “Increased serum levels of apelin in patients with cirrhosis,” Gastroenterology, vol. 136, p. A416, 2009. View at Google Scholar
  30. R. Bataller, P. Sancho-Bru, P. Ginès et al., “Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II,” Gastroenterology, vol. 125, no. 1, pp. 117–125, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. P. Lindahl, B. R. Johansson, P. Levéen, and C. Betsholtz, “Pericyte loss and microaneurysm formation in PDGF-B-deficient mice,” Science, vol. 277, no. 5323, pp. 242–245, 1997. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Lonardo, L. E. Adinolfi, P. Loria, N. Carulli, G. Ruggiero, and C. P. Day, “Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease,” Gastroenterology, vol. 126, no. 2, pp. 586–597, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. O. Kunduzova, N. Alet, N. Delesque-Touchard et al., “Apelin/APJ signaling system: a potential link between adipose tissue and endothelial angiogenic processes,” FASEB Journal, vol. 22, no. 12, pp. 4146–4153, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. J. R. Jonsson, H. D. Barrie, P. O'Rourke, A. D. Clouston, and E. E. Powell, “Obesity and steatosis influence serum and hepatic inflammatory markers in chronic hepatitis C,” Hepatology, vol. 48, no. 1, pp. 80–87, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Romero-Gomez, “Insulin resistance and hepatitis C,” World Journal of Gastroenterology, vol. 12, no. 44, pp. 7075–7080, 2006. View at Google Scholar · View at Scopus
  36. D. Daviaud, J. Boucher, S. Gesta et al., “TNFalpha up-regulates apelin expression in human and mouse adipose tissue,” FASEB Journal, vol. 20, no. 9, pp. 1528–1530, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. A. R. Zekri, M. S. Ashour, A. Hassan, H. M. A. El-Din, A. M. R. El-Shehaby, and M. A. Abu-Shady, “Cytokine profile in Egyptian hepatitis C virus genotype-4 in relation to liver disease progression,” World Journal of Gastroenterology, vol. 11, no. 42, pp. 6624–6630, 2005. View at Google Scholar · View at Scopus
  38. A. Goyal, S. N. Kazim, P. Sakhuja, V. Malhotra, N. Arora, and S. K. Sarin, “Association of TNF-beta polymorphism with disease severity among patients infected with hepatitis C virus,” Journal of Medical Virology, vol. 72, no. 1, pp. 60–65, 2004. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Toyoda, S. Kakizaki, N. Horiguchi et al., “Role of serum soluble Fas/soluble Fas ligand and TNF-α on response to interferon-α therapy in chronic hepatitis C,” Liver, vol. 20, no. 4, pp. 305–311, 2000. View at Publisher · View at Google Scholar · View at Scopus