Systemically Administered Ligands of Toll-Like Receptor 2, -4, and -9 Induce Distinct Inflammatory Responses in the Murine Lung

Table 2

MMP/TIMP mRNA ratios. MMP/TIMP mRNA ratios in control, LTA-, LPS- and CpG-stimulated pulmonary tissue. Values of mRNA expressions are normalized to L32 and expressed as arbitrary units (AU). Alphabetic characters indicate 𝑃-values<.05 from Bonferroni post-hoc testing (a = versus control, b = versus LTA, c = versus LPS, d = versus CpG-ODN; M ± SEM; 𝑛=4/group).

	Control	LTA		LPS		CpG
MMP-l/TIMP-l	0.00 ± 0.00	0.00 ± 0.00	c, d	0.07 ± 0.01	a, b, d	0.06 ± 0.02	b
MMP-2/TIMP-l	2.29 ± 0.13	5.10 ± 0.79	a, c	0.38 ± 0.08	b, d	4.19 ± 0.43	c
MMP-3/TIMP-l	0.22 ± 0.05	0.81 ± 0.20		0.39 ± 0.07		0.95 ± 0.44	a
MMP-8/TIMP-l	0.15 ± 0.02	2.28 ± 0.15		0.55 ± 0.09	d	4.45 ± 1.73	a, c
MMP-9/TIMP-l	0.11 ± 0.04	1.44 ± 0.08	a, c, d	0.12 ± 0.05	b	0.55 ± 0.18	b
MMP-l/TIMP-2	0.00 ± 0.00	0.00 ± 0.00	c	0.09 ± 0.02	a, b, d	0.01 ± 0.00	c
MMP-2/TIMP-2	0.09 ± 0.01	0.24 ± 0.16	d	0.41 ± 0.04	a, b, d	0.48 ± 0.05	a, b, c
MMP-3/TIMP-2	0.00 ± 0.00	0.04 ± 0.01	c	0.48 ± 0.15	a, b, d	0.11 ± 0.02	C
MMP-8/TIMP-2	0.01 ± 0.00	0.11 ± 0.01	c, d	0.60 ± 0.05	a, b	0.48 ± 0.13	a, b
MMP-9/TIMP-2	0.00 ± 0.00	0.07 ± 0.01		0.12 ± 0.04	a	0.06 ± 0.02
MMP-l/TIMP-3	0.00 ± 0.00	0.00 ± 0.00	c	0.04 ± 0.01	a, b, d	0.01 ± 0.00	c
MMP-2/TIMP-3	0.27 ± 0.04	0.70 ± 0.06	a, c	0.26 ± 0.10	b, d	0.64 ± 0.07	a, c
MMP-3/TIMP-3	0.03 ± 0.01	0.11 ± 0.02		0.24 ± 0.05	a	0.14 ± 0.03
MMP-8/TIMP-3	0.02 ± 0.00	0.32 ± 0.00		0.37 ± 0.12		0.61 ± 0.15	a
MMP-9/TIMP-3	0.01 ± 0.01	0.21 ± 0.02	a, d	0.09 ± 0.05		0.08 ± 0.02	b
Total MMP/TIMP	0.08 ± 0.01	0.33 ± 0.01	a, d	0.42 ± 0.08	a	0.60 ± 0.05	a, b