Emerging Role of PPAR-β/δ in Inflammatory Process Associated to Experimental Periodontitis
Figure 1
Effect of GW0742 on tissue damage and bone resorption. Inflammatory cells infiltration and edema were observed in gingivomucosal section from ligated rats (b) when compared with gingivomucosal tissue section taken from contralateral side (a). Significantly less edema and inflammatory cell infiltration was observed in gingivomucosal sections from ligature-treated rats which had been treated with GW0742 (c). Moreover, Masson’s trichrome stain was negative in gingivomucosal tissue sections taken from the contralateral side of vehicle when compared with gingivomucosal tissues sections of ligature-operated rats (d, e, resp.). GW0742 treatment reduced the increase of collagen (f). The alveolar bone from ligated rats demonstrated alveolar bone resorption (g). GW0742 treatment suppressed alveolar bone resorption (h). A significant increase in the distance between cementoenamel injunction and alveolar crest at mediolingulal root of the first molar was observed in ligature-treated rats (i). GW0742 treatment significantly reduced the increase in the distance between cementoenamel injunction and alveolar crest (i). Figures are representative of at least 3 experiments performed on different experimental days. The tissue sections, orientated longitudinally from the teeth crown, were stained with trichrome stain. Data represent 20 counts obtained from the gingivomucosal tissue of each treatment group. * versus nonligated. ° versus ligated.
