Emerging Role of PPAR-β/δ in Inflammatory Process Associated to Experimental Periodontitis

Figure 2

Effects of GW0742 treatment on NF-κB activation in periodontitis. A basal level of IκB-α was detected in the gingivomucosal tissue sections taken from the contralateral side (a, b). IκB-α levels were substantially reduced (a, b) in the gingivomucosal tissues from ligature-operated rats. GW0742 treatment prevented IκB-α degradation, (a, b). Periodontitis caused a significant increase in the NF-κB p65 levels in the gingivomucosal tissues from operated rats (c, d). GW0742 treatment significantly prevented NF-κB p65 expression (c, d). A representative blot of lysates obtained from 5 animals per group is shown and densitometry analysis of all animals is reported. The results in (b, d) are expressed as mean ± S.E.M. from 𝑛=5/6 gingivomucosal tissues for each group. *𝑃<0.01 versus nonligated group. °𝑃<0.01 versus ligated group.