Beneficial Effects of Ethyl Pyruvate through Inhibiting High-Mobility Group Box 1 Expression and TLR4/NF-B Pathway after Traumatic Brain Injury in the Rat
Figure 6
NF-κB DNA binding activity in the brain tissue surrounding the contusion cortex in Sham group, TBI group, and TBI + EP group. Upper panel: EMSA autoradiography of NF-κB DNA binding activity. Lower panel: quantification of NF-κB DNA binding activity was performed by densitometric analysis. As compared with Sham group, NF-κB binding activity measured by EMSA was significantly increased after TBI. However, compared to TBI group, EP treatment significantly suppressed NF-κB binding activation in TBI + EP group. Bars represent as mean ± SEM; , each group; **P versus Sham group, versus TBI group.
