Beneficial Effects of Ethyl Pyruvate through Inhibiting High-Mobility Group Box 1 Expression and TLR4/NF-B Pathway after Traumatic Brain Injury in the Rat
Figure 7
Changes of inflammatory mediators in the injured brain of rats determined by ELISA in Sham group, TBI group, and TBI + EP group. The figure indicated that the levels of TNF-α, IL-1β, and IL-6 in the injured brain tissue were significantly increased after TBI. In the TBI + EP group, the concentrations of TNF-α, IL-1β, and IL-6 were markedly downregulated when treated with EP. Bars represent as mean ± SEM; , each group; **P compared with Sham group, #P, ##P compared with TBI group.
