Progesterone Administration Modulates Cortical TLR4/NF-κB Signaling Pathway after Subarachnoid Hemorrhage in Male Rats
Figure 4
Changes of inflammatory mediators in the injured brains as determined by ELISA in control group (), SAH group (), SAH + vehicle group (), and SAH + progesterone group (). SAH could induce the significantly increased concentrations of IL-1β, TNF-α and IL-6 in the rat brain surrounding the blood clot. In SAH + progesterone group, the cortical concentrations of IL-1β, TNF-α and IL-6 were markedly down-regulated as compared with that of SAH + vehicle group. Bars represent the mean ± SD (, each group). ** compared with control group, # compared with SAH + vehicle group, ## compared with SAH + vehicle group, ns compared with SAH group.
