Angiogenesis-Related Cytokines, RANKL, and Osteoprotegerin in Multiple Myeloma Patients in relation to Clinical Features and Response to Treatment

Table 5

Mean ± SD values of the measured parameters in MM patients before and after treatment.

		Mean ± SD	𝑃 (Wilcoxon test)
OPG (pmol/L)	Before treatment	11.5±10.9	< 0.03
	After treatment	13.3±14.0
RANKL (pmol/L)	Before treatment	335.10±306.68	< 0.005
	After treatment	99.95±108.52
RANKL/OPG	Before treatment	76.55±96.25	< 0.01
	After treatment	10.81±9.91
HGF (pg/mL)	Before treatment	1433.0±1100.9	< 0.001
	After treatment	765.9±210.5
LDH (IU/L)	Before treatment	218.6±76.0	< 0.002
	After treatment	176.1±33.4
VEGF (pg/mL)	Before treatment	243.8±177.0	< 0.001
	After treatment	120.7±40.4
IL-6 (pg/mL)	Before treatment	3.5±3.6	< 0.003
	After treatment	2.4±1.2