Deviations in Circulating TNF Levels and TNF Production by Mononuclear Cells in Healthy Human Populations
Figure 4
In vitro TNFα productions by peripheral blood mononuclear cells (PBMCs) of young volunteers demonstrate significant interindividual differences in this group (a) based on the order of TNFα production (b) three subgroups can be distinguished: downregulated, intermediate, and upregulated (c) no response to endotoxin (LPS) was found in the majority of downregulated group (d), stimulated versus nonstimulated.
(a) In vitro TNF alpha values by PBMCs in young volunteers
(b) Basal TNF alpha values by PBMCs in order in young volunteers
(c) Inducibility of PBMCs by LPS in young volunteers
(d) Inducibility of PBMCs by LPS in downregulated subgroup of young volunteers
