Mediators of Inflammation / 2012 / Article / Tab 4

Research Article

A Comparative In Vitro Study of the Effects of Separate and Combined Products of Citrus e fructibus and Cydonia e fructibus on Immunological Parameters of Seasonal Allergic Rhinitis

Table 4

Summary of effects on days 1 and 7 in the SAR group, healthy group, and total group.

Cytokines (immunological SAR-related subset) on day 1 and day 7SAR groupHealthy groupTotal group
CI versus CYCI versus CI/CYCY versus CI/CYCI versus CYCI versus CI/CYCY versus CI/CYCI versus CYCI versus CI/CYCY versus CI/CY

Day 1
IL-1β (Th2)CI*CI**CI**CI***CI**
TNF-α (Chr. Inf.)CI***CI*CI**CI*CI***CI***
IFN-γ (Th1)CY**CI/CY**CY**CI/CY*CY***CI/CY***
IL-10/TNF-α (Treg/Chr. Inf)CI***CI**CI**CI**
Day 7
IL-10 (Treg)CI/CY*
IL-5 (Th2)CI**CI**CI***CI**CI***
IL-13 (Th2)CI*
IFN-γ (Th1)CY*CY*CY*
IFN-γ/IL-5 (Th1/Th2)CI**CY*CI**CI***

*: ; **: ; ***: ; CI = Citrus; CY = Cydonia; CI/CY = Citrus/Cydonia, Treg = regulatory T cells; Th2 = SAR-related Th2 pathway; Th1 = SAR-related Th1 pathway; Chron. Inf. = SAR-related chronic inflammatory activity. Example: CI** (CI versus CY): Citrus (in relation to Cydonia) demonstrates an SAR-related treatment effect with a statistically significant difference < 0.01.

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