Deoxyribonuclease Is a Potential Counter Regulator of Aberrant Neutrophil Extracellular Traps Formation after Major Trauma

Figure 1

Kinetics of cfDNA/NETs after major trauma. (a) cf-DNA/NETs levels in patients (𝑛=39) were significantly enhanced after trauma (𝑃<0.01), versus control group (healthy volunteers). *𝑃<0.05, **𝑃<0.01, and ***𝑃<0.0001, (b) cfDNA/NETs levels in patients who developed sepsis during the first 10 days after trauma (𝑛=14) were significantly elevated when compared to the values determined in patients with uneventful recovery (𝑛=25). The horizontal line across the boxplots represents the median, and the lower and upper ends of the boxplots are the 25th and 75th percentiles, respectively. Whiskers indicate the minimum and maximum values, respectively versus no sepsis group at the same time. ^#𝑃<0.05, ^##𝑃<0.01 and ^###𝑃<0.0001.

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