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Mediators of Inflammation
Volume 2012 (2012), Article ID 159354, 7 pages
http://dx.doi.org/10.1155/2012/159354
Review Article

Macrolides in Chronic Inflammatory Skin Disorders

1Dermatology Department, College of Medicine, Qassim University, P.O. Box 30109, Buraidah 51477, Saudi Arabia
2Pediatric Department, College of Medicine, Qassim University, P.O. Box 30109, Buraidah 51477, Saudi Arabia

Received 21 January 2012; Revised 10 March 2012; Accepted 15 March 2012

Academic Editor: Kazuhito Asano

Copyright © 2012 Abdullateef A. Alzolibani and Khaled Zedan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Long-term therapy with the macrolide antibiotic erythromycin was shown to alter the clinical course of diffuse panbronchiolitis in the late 1980s. Since that time, macrolides have been found to have a large number of anti-inflammatory properties in addition to being antimicrobials. These observations provided the rationale for many studies performed to assess the usefulness of macrolides in other inflammatory diseases including skin and hair disorders, such as rosacea, psoriasis, pityriasis rosea, alopecia areata, bullous pemphigoid, and pityriasis lichenoides. This paper summarizes a collection of clinical studies and case reports dealing with the potential benefits of macrolides antibiotics in the treatment of selected dermatoses which have primarily been classified as noninfectious and demonstrating their potential for being disease-modifying agents.