Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2012, Article ID 159354, 7 pages
http://dx.doi.org/10.1155/2012/159354
Review Article

Macrolides in Chronic Inflammatory Skin Disorders

1Dermatology Department, College of Medicine, Qassim University, P.O. Box 30109, Buraidah 51477, Saudi Arabia
2Pediatric Department, College of Medicine, Qassim University, P.O. Box 30109, Buraidah 51477, Saudi Arabia

Received 21 January 2012; Revised 10 March 2012; Accepted 15 March 2012

Academic Editor: Kazuhito Asano

Copyright © 2012 Abdullateef A. Alzolibani and Khaled Zedan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. A. Washington and W. R. Wilson, “Erythromycin: a microbial and clinical perspective after 30 years of clinical use,” Mayo Clinic Proceedings, vol. 60, no. 3, pp. 189–203, 1985. View at Google Scholar · View at Scopus
  2. Y. S. López-Boado and B. K. Rubin, “Macrolides as immunomodulatory medications for the therapy of chronic lung diseases,” Current Opinion in Pharmacology, vol. 8, no. 3, pp. 286–291, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. D. P. Healy, “Macrolide immunomodulation of chronic respiratory diseases,” Current Infectious Disease Reports, vol. 9, no. 1, pp. 7–13, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. D. F. Florescu, P. J. Murphy, and A. C. Kalil, “Effects of prolonged use of azithromycin in patients with cystic fibrosis: a meta-analysis,” Pulmonary Pharmacology and Therapeutics, vol. 22, no. 6, pp. 467–472, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. M. S. Whitman and A. R. Tunkel, “Azithromycin and clarithromycin: overview and comparison with erythromycin,” Infection Control and Hospital Epidemiology, vol. 13, no. 6, pp. 357–368, 1992. View at Google Scholar · View at Scopus
  6. I. H. Itkin and M. L. Menzel, “The use of macrolide antibiotic substances in the treatment of asthma,” Journal of Allergy, vol. 45, no. 3, pp. 146–162, 1970. View at Google Scholar · View at Scopus
  7. M. Shinkai and B. K. Rubin, “Macrolides and airway inflammation in children,” Paediatric Respiratory Reviews, vol. 6, no. 3, pp. 227–235, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Brinkmeier and P. J. Frosch, “Oral antibiotics with antiinflammatory/immunomodulatory effects in the treatment of various dermatoses,” Hautarzt, vol. 53, no. 7, pp. 456–465, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. S. L. Spector, F. H. Katz, and R. S. Farr, “Troleandomycin: effectiveness in steroid dependent asthma and bronchitis,” Journal of Allergy and Clinical Immunology, vol. 54, no. 6, pp. 367–379, 1974. View at Google Scholar · View at Scopus
  10. S. Kudoh, T. Uetake, K. Hagiwara, M. Hirayama, L. H. Hus, H. Kimura et al., “Clinical effects of low-dose long-term erythromycin chemotherapy on diffuse panbronchiolitis,” Nihon Kyobu Shikkan Gakkai Zasshi, vol. 25, pp. 632–642, 1987. View at Google Scholar
  11. J. Tamaoki, K. Takeyama, E. Tagaya, and K. Konno, “Effect of clarithromycin on sputum production and its rheological properties in chronic respiratory tract infections,” Antimicrobial Agents and Chemotherapy, vol. 39, no. 8, pp. 1688–1690, 1995. View at Google Scholar · View at Scopus
  12. S. Kudoh, A. Azuma, M. Yamamoto, T. Izumi, and M. Ando, “Improvement of survival in patients with diffuse panbronchiolitis treated with low-dose erythromycin,” American Journal of Respiratory and Critical Care Medicine, vol. 157, no. 6, pp. 1829–1832, 1998. View at Google Scholar · View at Scopus
  13. S. Umeki, “Anti-inflammatory action of erythromycin: its inhibitory effect on neutrophil NADPH oxidase activity,” Chest, vol. 104, no. 4, pp. 1191–1193, 1993. View at Google Scholar · View at Scopus
  14. M. T. Labro, “Anti-inflammatory activity of macrolides: a new therapeutic potential?” Journal of Antimicrobial Chemotherapy, vol. 41, pp. 37–46, 1998. View at Publisher · View at Google Scholar · View at Scopus
  15. L. Wu, W. Zhang, L. Tian, K. Bao, P. Li, and J. Lin, “Immunomodulatory effects of erythromycin and its derivatives on human T-lymphocyte in vitro,” Immunopharmacology and Immunotoxicology, vol. 29, no. 3-4, pp. 587–596, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. W. D. James, T. G. Berger, and D. M. Elston, Andrew's Diseases of the Skin, WB Saunders, Philadelphia, Pa, USA, 10th edition, 2006.
  17. J. Q. Del Rosso, “Systemic therapy for rosacea: focus on oral antibiotic therapy and safety,” Cutis, vol. 66, supplement 4, pp. 7–13, 2000. View at Google Scholar · View at Scopus
  18. P. Humbert, P. Treffel, J. F. Chapuis, S. Buchet, C. Derancourt, and P. Agache, “The tetracyclines in dermatology,” Journal of the American Academy of Dermatology, vol. 25, no. 4, pp. 691–697, 1991. View at Google Scholar · View at Scopus
  19. O. Bakar, Z. Demirçay, M. Yuksel, G. Haklar, and Y. Sanisoglu, “The effect of azithromycin on reactive oxygen species in rosacea,” Clinical and Experimental Dermatology, vol. 32, no. 2, pp. 197–200, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Fernandez-Obregon, “Oral use of azithromycin for the treatment of acne rosacea,” Archives of Dermatology, vol. 140, no. 4, pp. 489–490, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Modi, M. Harting, and T. Rosen, “Azithromycin as an alternative rosacea therapy when tetracyclines prove problematic,” Journal of Drugs in Dermatology, vol. 7, no. 9, pp. 898–899, 2008. View at Google Scholar · View at Scopus
  22. M. Akhyani, A. H. Ehsani, M. Ghiasi, and A. K. Jafari, “Comparison of efficacy of azithromycin vs. doxycycline in the treatment of rosacea: a randomized open clinical trial,” International Journal of Dermatology, vol. 47, no. 3, pp. 284–288, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. J. H. Kim, Y. S. Oh, and E. H. Choi, “Oral azithromycin for treatment of intractable rosacea,” Journal of Korean Medical Science, vol. 26, no. 5, pp. 694–696, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Thanou-Stavraki, T. aberle, I. Aksentijevich, B. L. Bane, and J. B. Harley, “Clarithromycin in adult-onset still's disease: a potentially useful therapeutic,” Journal of Clinical Rheumatology, vol. 17, no. 7, pp. 373–376, 2011. View at Google Scholar
  25. G. Saviola, M. Benucci, L. Abdi-Ali et al., “Clarithromycin in adult-onset Still's disease: a study of 6 cases,” Rheumatology International, vol. 30, no. 4, pp. 555–560, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. A. M. Chamot, C. L. Benhamou, M. F. Kahn, L. Beraneck, G. Kaplan, and A. Prost, “Acne- pustulosis- hyperostosis- osteitis syndrome. Results of a national survey: 85 cases,” Revue du Rhumatisme et des Maladies Osteo-Articulaires, vol. 54, pp. 187–196, 1987. View at Google Scholar
  27. M. Colina, A. Lo Monaco, M. Khodeir, and F. Trotta, “Propionibacterium acnes and SAPHO syndrome: a case report and literature review,” Clinical and Experimental Rheumatology, vol. 25, no. 3, pp. 457–460, 2007. View at Google Scholar · View at Scopus
  28. T. Schaeverbeke, L. Lequen, B. de Barbeyrac et al., “Propionibacterium acnes isolated from synovial tissue and fluid in a patient with oligoarthritis associated with acne and pustulosis,” Arthritis & Rheumatism, vol. 41, pp. 1889–1893, 1998. View at Google Scholar
  29. T. Kirchhoff, S. Merkesdal, H. Rosenthal et al., “Diagnostic management of patients with SAPHO syndrome: use of MR imaging to guide bone biopsy at CT for microbiological and histological work-up,” European Radiology, vol. 13, no. 10, pp. 2304–2308, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. G. Assmann, O. Kueck, T. Kirchhoff et al., “Efficacy of antibiotic therapy for SAPHO syndrome is lost after its discontinuation: an interventional study,” Arthritis Research and Therapy, vol. 11, no. 5, article R140, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. C. Matzaroglou, D. Velissaris, A. Karageorgos, M. Marangos, E. Panagiotopoulos, and M. Karanikolas, “SAPHO syndrome diagnosis and treatment: report of five cases and review of the literature,” The Open Orthopaedics Journal, vol. 3, pp. 100–106, 2009. View at Google Scholar
  32. D. D. Balci, N. Duran, B. Ozer, R. Gunessacar, Y. Onlen, and J. Z. Yenin, “High prevalence of Staphylococcus aureus cultivation and super-antigen production in patients with psoriasis,” European Journal of Dermatology, vol. 19, pp. 238–242, 2009. View at Google Scholar
  33. M. Komine and K. Tamaki, “An open trial of oral macrolide treatment for psoriasis vulgaris,” Journal of Dermatology, vol. 27, no. 8, pp. 508–512, 2000. View at Google Scholar · View at Scopus
  34. J. Tamaoki, J. Kadota, and H. Takizawa, “Clinical implications of the immunomodulatory effects of macrolides,” The American Journal of Medicine, vol. 117, supplement 9, pp. 5s–11s, 2004. View at Google Scholar · View at Scopus
  35. C. M. Owen, R. J. G. Chalmers, T. O'Sullivan, and C. E. M. Griffiths, “A systematic review of antistreptococcal interventions for guttate and chronic plaque psoriasis,” British Journal of Dermatology, vol. 145, no. 6, pp. 886–890, 2001. View at Publisher · View at Google Scholar · View at Scopus
  36. J. K. Wilson, S. N. Al-Suwaidan, D. Krowchuk, and S. R. Feldman, “Treatment of psoriasis in children: is there a role for antibiotic therapy and tonsillectomy?” Pediatric Dermatology, vol. 20, no. 1, pp. 11–15, 2003. View at Publisher · View at Google Scholar · View at Scopus
  37. H. Valdimarsson, H. Sigmundsdottir, and I. Jonsdottir, “Is psoriasis induced by streptococcal super antigens and maintained by M- protein specific T cells that cross react with keratin?” Clinical & Experimental Immunology, vol. 107, pp. 21–24, 1997. View at Google Scholar
  38. J. C. Prinz, “Psoriasis vulgaris- a sterile anti-bacterial skin reaction mediated by cross reactive T cells? An immunological view of the patho physiology of psoriasis,” Clinical and Experimental Dermatology, vol. 26, pp. 326–332, 2001. View at Google Scholar
  39. A. Ohshima, M. Takigawa, and Y. Tokura, “CD8+ cell changes in psoriasis associated with roxithromycin-induced clinical improvement,” European Journal of Dermatology, vol. 11, no. 5, pp. 410–415, 2001. View at Google Scholar · View at Scopus
  40. S. Konno, M. Adachi, K. Asano, K. Okamoto, and T. Takahashi, “Inhibition of human T-lymphocyte activation by macrolide antibiotic, roxithromycin,” Life Sciences, vol. 51, no. 24, pp. 231–236, 1992. View at Google Scholar · View at Scopus
  41. H. Wakita, Y. Tokura, F. Furukawa, and M. Takigawa, “The macrolide antibiotic, roxithromycin suppresses IFN-γ-mediated immunological functions of cultured normal human keratinocytes,” Biological and Pharmaceutical Bulletin, vol. 19, no. 2, pp. 224–227, 1996. View at Google Scholar · View at Scopus
  42. V. N. Saxena and J. Dogra, “Long-term oral azithromycin in chronic plaque psoriasis: a controlled trial,” European Journal of Dermatology, vol. 20, no. 3, pp. 329–333, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. K. Tamaki, “Antipruritic effect of macrolide antibiotics,” Journal of Dermatology, vol. 27, no. 1, pp. 66–67, 2000. View at Google Scholar · View at Scopus
  44. M. Polat, N. Lenk, B. Yalcin et al., “Efficacy of erythromycin for psoriasis vulgaris,” Clinical and Experimental Dermatology, vol. 32, no. 3, pp. 295–297, 2007. View at Publisher · View at Google Scholar · View at Scopus
  45. G. Campuzano-Maya, “Cure of alopecia areata after eradication of helicobacter pylori: a new association,” World Journal of Gastroenterology, vol. 17, no. 26, pp. 3165–3170, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. L. Ben Mahmoud, H. Ghozzi, A. Hakim, Z. Sahnoun, and K. Zeghal, “Helicobacter pylori associated with chronic urticaria,” Journal of Infection in Developing Countries, vol. 5, no. 8, pp. 596–598, 2011. View at Google Scholar
  47. P. K. Sharma, T. P. Yadav, R. K. Gautam, N. Taneja, and L. Satyanarayana, “Erythromycin pityriasis rosea: a double-blind, placebo-controlled clinical trial,” Journal of the American Academy of Dermatology, vol. 42, no. 2, pp. 241–244, 2000. View at Google Scholar · View at Scopus
  48. A. Rasi, L. Tajziehchi, and S. Savabi-Nasab, “Oral erythromycin is ineffective in the treatment of pityriasis rosea,” Journal of Drugs in Dermatology, vol. 7, no. 1, pp. 35–38, 2008. View at Google Scholar · View at Scopus
  49. A. Chuh, A. Lee, V. Zawar, G. Sciallia, and W. Kempf, “Pityriasis rosea—an update,” Indian Journal of Dermatology, Venereology and Leprology, vol. 71, no. 5, pp. 311–315, 2005. View at Google Scholar
  50. A. P. Truhan, A. A. Hebert, and N. B. Esterly, “Pityriasis lichenoides in children: therapeutic response to erythromycin,” Journal of the American Academy of Dermatology, vol. 15, no. 1, pp. 66–70, 1986. View at Google Scholar · View at Scopus
  51. R. B. Skinner and A. L. Levy, “Rapid resolution of pityriasis lichenoides etvarioliformis acuta with azithromycin,” Journal of the American Academy of Dermatology, vol. 58, no. 3, pp. 524–525, 2008. View at Publisher · View at Google Scholar · View at Scopus
  52. H. Mensing and S. Krausse, “Erythromycin treatment for bullous pemphigoid,” Medizinische Klinik, vol. 85, no. 8, pp. 481–484, 1990. View at Google Scholar · View at Scopus
  53. G. Altomare, G. L. Capella, C. Fracchiolla, and E. Frigerio, “Treatment of bullous pemphigoid with erythromycin: a reappraisal,” European Journal of Dermatology, vol. 9, no. 7, pp. 583–585, 1999. View at Google Scholar · View at Scopus
  54. B. J. Fox, R. B. Odom, and R. F. Findlay, “Erythromycin therapy in bullous pemphigoid: possible anti-inflammatory effects,” Journal of the American Academy of Dermatology, vol. 7, no. 4, pp. 504–510, 1982. View at Google Scholar · View at Scopus
  55. M. Ohe and S. Hashino, “Successful treatment with erythromycin for idiopathic thrombocytopenic purpura,” Korean Journal of Hematology, vol. 46, no. 2, pp. 140–142, 2011. View at Google Scholar
  56. M. Ohe and M. Kohno, “Three cases of idiopathic thrombocytopenic purpura showing an increase in the platelet count following clarithromycin treatment,” Rinsho Ketsueki, vol. 44, pp. 1044–1046, 2003. View at Google Scholar
  57. H. Tlaskalova-Hogenova, R. Stepankova, T. Hudcovic et al., “Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases,” Immunology Letters, vol. 93, pp. 97–108, 2004. View at Google Scholar