Mediators of Inflammation / 2012 / Article / Tab 2

Research Article

Symptoms, but Not a Biomarker Response to Inhaled Corticosteroids, Predict Asthma in Preschool Children with Recurrent Wheeze

Table 2

Baseline analysis at preschool age.

Median (IQR) transient wheezeMedian (IQR) asthmaOR95% CI

IL-1α, in pg/mL34.0 (15.6–83.7)44.2 (18.3–97.6)1.100.84–1.44
IL-2, in pg/mL55.5 (35.7–76.8)57.0 (43.1–81.2)1.320.80–2.16
IL-4, in pg/mL8.8 (4.8–13.9)9.6 (6.0–14.5)1.150.70–1.88
IL-5, in pg/mL29.8 (17.8–58.7)37.2 (19.4–80.6)1.210.85–1.73
IL-10, in pg/mL4.5 (2.8–6.9)5.2 (3.2–8.4)1.090.72–1.65
IFN-γ, in pg/mL28.1 (17.5–44.6)27.1 (16.0–44.2)0.880.67–1.16
sICAM, in pg/mL190.4 (94.8–416.2)265.5 (104.1–516.4)1.080.79–1.48
CCL-11, in pg/mL8.3 (5.2–12.5))8.0 (5.3–14.6)0.900.71–1.15
pH6.0 (5.7–6.3)5.8 (5.6–6.2)0.660.34–1.28
FeNO, in ppb6.7 (3.7–13.3)8.9 (5.4–18.1)1.020.98–1.05
Airway resistance before medication§1.4 (0.3)1.5 (0.4)2.150.83–5.56
Airway resistance after medication§1.2 (0.4)1.3 (0.3)2.060.70–6.01
Bronchodilator response§0.1 (0.3)0.0 (0.5)1.440.45–4.55
Total symptom score*27 (25–29)25 (20–28)0.850.77–0.93

*False Discovery Rate (FDR) corrected ; §mean (standard deviation).
IL: interleukin; IFN-γ: interferon-γ; sICAM: soluble Intercellular Adhesion Molecule; CCL-11: Eotaxin; FeNO: Fractional exhaled Nitric Oxide; OR: odds ratio; 95% CI: 95% confidence interval. Analysis adjusted for gender atopy, eczema, previous inhaled corticosteroids use, asthma first relative, smoking exposure, and season of measurement. The transient wheeze group is the reference group.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.