Symptoms, but Not a Biomarker Response to Inhaled Corticosteroids, Predict Asthma in Preschool Children with Recurrent Wheeze

Table 3

Changes induced by inhaled corticosteroids related to an asthma diagnosis.

	OR	95% CI
IL-1α	0.96	0.78–1.19
IL-2	0.99	0.71–1.38
IL-4	0.90	0.64–1.28
IL-5	0.97	0.76–1.24
IL-10	0.87	0.65–1.16
IFN-γ	0.93	0.73–1.20
sICAM	0.97	0.77–1.22
CCL-11	0.94	0.75–1.17
pH	0.99	0.61–1.60
FeNO	1.01	0.99–1.04
Airway resistance before medication	0.80	0.33–1.93
Airway resistance after medication	1.51	0.55–4.16
Total symptom score decreased	Ref.
Total symptom score equal	0.74	0.27–2.04
Total symptom score increased	0.65	0.30–1.39

IL: interleukin; IFN-γ: interferon-γ; sICAM: soluble Intercellular Adhesion Molecule; CCL-11: Eotaxin; FeNO: Fractional exhaled Nitric Oxide; OR: odds ratio; 95% CI: 95% confidence interval; Ref.: reference category. Analysis adjusted for gender atopy, eczema, previous inhaled corticosteroids use, asthma first relative, smoking exposure, and season of measurement. The transient wheeze group is the reference group. Due to violation of linearity assumption in log transformation, results for total symptom score are split up into three equal categories.