Research Article
Distinct Proteasome Subpopulations in the Alveolar Space of Patients with the Acute Respiratory Distress Syndrome
Table 2
Specific activities of proteasomes isolated from healthy controls and ARDS patients.
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Proteolytic activities of purified 20S proteasome from BAL supernatant of healthy controls and of ARDS patients, as measured with specific proteasomal fluorogenic substrates. BAL supernatants were pooled from 5 healthy subjects and from 5 ARDS patients, respectively. The ratio of enzyme activities differs between ARDS patients and healthy subjects, suggesting a rearrangement of proteasomal subunit composition. PGPH: peptidyl-glutamyl peptide-hydrolysing activity; Try: trypsin-like activity; Chtr: chymotrypsin-like activity. |