L-Arginine and Asymmetric Dimethylarginine Are Early Predictors for Survival in Septic Patients with Acute Liver Failure
Table 2
L-arg and ADMA measurements in different subgroups of patients with septic shock.
Parameters
Units
L-arg and ADMA measurements in different subgroups of patients with septic shock
Timepoints
Onset
24 h
4 d
7 d
14 d
28 d
Survival:
Survivors at Day 28 (italic parts ) versus Non-Survivors at Day 28 (bold parts, )
L-arg
[μmol/L]
77.9; 62.1–115.3
n.s.
107.1; 65.9–150.1
*
154.2; 113.4–228.8
n.s.
97.0; 76.5–154.8
*
98.4; 67.7–125.0
n.s.
99.8; 66.4–138.3
Ø
123.7; 66.1–175.4
158.4; 88.2–201.5
197.5; 149.7–240.0
172.2; 161.8–195.9
112.1; 102.1–145.3
Ø
ADMA
[μmol/L]
0.74; 0.52–0.92
n.s.
0.84; 0.67–1.08
n.s.
0.95; 0.72–1.11
n.s.
0.80; 0.63–1.05
n.s.
0.83; 0.70–1.04
n.s.
0.86; 0.67–0.99
Ø
0.83; 0.61–1.21
0.87; 0.67–1.29
0.87; 0.71–1.27
0.83; 0.77–1.14
0.75; 0.60–0.91
Ø
L-arg/ADMA-Ratio
[none]
126.5; 91.5–164.8
n.s.
135.0; 95.0–197.8
n.s.
154.0; 123.0–191.5
n.s.
121.5; 97.5–160.5
*
111.0; 83.5–155.8
n.s.
118.0; 89.5–180.5
Ø
118.5; 91.5–157.0
142.5; 105.0–186.5
196.0; 138.0–235.5
185.0; 143.5–240.0
191.0; 165.3–204.8
Ø
Pulmonary:
Patients with ARDS (italic parts, ) versus Non-ARDS (bold parts, )
L-arg
[μmol/L]
84.6; 61.4–145.9
n.s.
114.3; 72.9–161.0
n.s.
167.5; 132.6–242.1
*
106.8; 84.7–172.2
n.s.
102.9; 69.2–128.8
n.s.
120.0; 66.7–149.3
n.s.
94.6; 83.5–140.9
187.8; 152.2–228.0
76.0; 57.4–108.5
109.6; 91.2–168.5
150.8; 117.4–184.1
99.8; 99.8-99.8
ADMA
[μmol/L]
0.81; 0.61–0.93
n.s.
0.85; 0.69–1.08
n.s.
1.00; 0.72–1.19
n.s.
0.80; 0.68–1.05
n.s.
0.82; 0.68–1.03
n.s.
0.85; 0.67–1.00
n.s.
0.55; 0.53–1.67
0.74; 0.67–1.62
0.78; 0.68–0.89
0.83; 0.71–1.03
0.84; 0.78–0.91
0.90; 0.90-0.90
L-arg/ADMA-Ratio
[none]
124.0; 90.0–162.0
n.s.
141.0; 97.5–183.5
n.s.
172.5; 129.0–215.5
n.s.
137.0; 102.0–171.0
n.s.
120.0; 93.0–162.0
n.s.
128.0; 90.3–179.8
n.s.
109.0; 88.5–158.0
169.5; 107.5–324.5
111.0; 80.3–142.3
132.0; 127.0–158.5
170.0; 144.0–196.0
110.0; 110.0-110.0
Renal:
Patients with ARF (italic parts, ) versus Non-ARF (grey boxes, )
L-arg
[μmol/L]
95.8; 60.3–150.5
n.s.
114.3; 76.3–192.7
n.s.
185.9; 140.7–246.7
*
147.8; 86.7–180.9
n.s.
101.6; 69.0–146.6
n.s.
120.8; 65.6–147.6
n.s.
87.8; 67.0–142.7
134.7; 72.6–160.4
142.1; 105.3–162.9
99.1; 75.9–117.0
96.5; 68.1–111.6
81.6; 69.7–96.3
ADMA
[μmol/L]
0.82; 0.59–1.09
n.s.
0.86; 0.66–1.10
n.s.
1.02; 0.75–1.35
*
0.92; 0.75–1.26
*
0.85; 0.67–1.01
n.s.
0.85; 0.67–0.98
n.s.
0.73; 0.51–0.86
0.83; 0.67–1.03
0.87; 0.68–1.01
0.79; 0.59–0.85
0.83; 0.70–1.06
0.91; 0.53–1.01
L-arg/ADMA-Ratio
[none]
118.0; 95.0–160.5
n.s.
122.0; 98.0–179.0
n.s.
172.0; 129.0–196.0
n.s.
141.0; 105.5–169.5
n.s.
123.5; 93.5–168.0
n.s.
138.0; 94.0–179.0
n.s.
126.0; 88.3–169.8
146.5; 100.0–207.0
154.0; 109.0–230.0
120.5; 97.5–188.8
100.0; 75.5–125.5
96.0; 65.5–172.3
Data are presented by median and interquartile range (Q1–Q3). Concerning symbolism and higher orders of significance: P < 0.05: *, P < 0.01: **, P < 0.001: ***, n.s.: not statistically significant, Ø: no data available. Abbreviations: L-arg, L-arginine; ADMA, asymmetric dimethylarginine; ARDS, acute respiratory distress syndrome; ARF, acute renal failure.
