The Absence of Nrf2 Enhances NF-𝜿B-Dependent Inflammation following Scratch Injury in Mouse Primary Cultured Astrocytes

Figure 2

EMSA analysis for DNA-binding activity of NF-κB. (a) Representative film shows DNA-binding activity of NF-κB in Nrf2 WT or KO astrocytes 24 h after scratch or not. (b) Quantification of NF-κB DNA-binding activity was performed by ImageJ. NF-κB DNA-binding activity in astrocytes increased after scratch (𝑃<0.01) and was prominently greater in group KO TBI than in group WT TBI (𝑃<0.01). (*𝑃<0.01, compared with sham counterpart; ^#𝑃<0.01, compared with WT TBI).

(a)

(b)