Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals
Table 1
Characteristics of the study population.
Nonobese subjects
Obese subjects
P value
()
()
Age, yrs
42.5 (36–49)
44 (36–56)
0.36
Male Gender (%)
56 (27)
60 (26)
0.83
BMI, kg/m2
25.6 (22.1–27.3)
41.3 (31.8–45.0)
<0.0001
Waist, cm
92.3 (84.5–100.5)
117.5 (111–124)
<0.0001
Waist-hip ratio
0.88 (0.83–0.92)
0.96 (0.90–1.00)
<0.0001
Total fat amount, kg
16.7 (13.5–20.9)
42.3 (29.5–58.3)
<0.0001
Body fat, %
22.5 (19.0–27.8)
38.2 (30–46.7)
<0.0001
Cholesterol levels, mg/dL
195 (169.7–226.2)
195 (167.7–226.2)
0.81
LDL level, mg/dL
126.9 (110.8–147)
120.1 (102.2–143.9)
0.33
HDL level, mg/dL
48.8 (39.4–59.7)
42.3 (37.8–46.8)
0.01
Triglyceride level, mg/dL
74.3 (53.8–106.4)
122.4 (82.8–188.7)
<0.0001
Glucose level, mg/dL
94.6 (86.5–102.7)
99.5 (91.9–108.1)
0.01
Insulin, mUI/L
4.8 (1.9–7.8)
9.95 (6.4–19.5)
0.0001
HOMA
1.2 (0.5–1.8)
2.26 (1.65–4.60)
0.0001
Hs-CRP, mg/L
0.9 (0.9–2.9)
5.0 (2.9–8.5)
<0.0001
HbAlc, %
5.2 (5.05–5.4)
5.4 (5.2–5.7)
0.01
FRS, %
1 (0.9–3.0)
2 (0.9–5)
0.07
Anti-ApoA-1 IgG index
9.3 (2.4–20.5)
18.9 (11.4–25.3)
0.0003
Anti-ApoA-1 IgG positivity, % (n)
0 (0)
14 (6)
0.009
Values are medians (Interquartile Range (IQR)), unless indicated otherwise. BMI: body mass index; hs-CRP: high sensitive C-reactive protein; HbAlc: haemoglobin Alc; HDL: high-density lipoprotein; HOMA: Homeostasis Model Assessment; LDL: low-density lipoprotein; FRS: Framingham Risk Score. P values according to Mann-Whitney U-test for continuous values and according to bilateral exact Fisher test for proportions.
