Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals
Table 2
Coronary artery calcification (CAC) score, myocardial blood flow (MBF) and hemodynamic parameters during PET studies.
Nonobese subjects
Obese subjects
P value
()
()
Coronary calcification
Agatston score
0 (0-0; 0–86.9)
0 (0-0; 0–77.1)
0.88
Subjects with CAC > 0, % (n)
13 (6)
14 (6)
1
Myocardial blood flow, MBF (mL/min/g) at rest
MBF at rest
0.70 (0.63–0.76)
0.78 (0.66–0.90)
0.01
NMBF at rest
0.97 (0.85–1.12)
0.94 (0.86–1.13)
0.88
MBF during CPT
0.92 (0.80–1.06)
0.85 (0.75–0.95)
0.08
ΔMBF to CPT from rest
0.25 (0.16–0.31)
0.10 (0.03–0.16)
<0.0001
ΔMBF to CPT < 0.3, % (n)
73 (35)
93 (40)
0.01
NMBF during CPT
0.97 (0.88–1.14)
0.77 (0.69–0.91)
<0.0001
MBF during hyperemia
2.12 (1.79–2.47)
2.10 (1.72–2.42)
0.46
MFR
3.13 (2.57–3.60)
2.69 (2.21–3.30)
0.01
MBF hyperemia/NMBF rest
2.18 (1.86–2.64)
2.24 (2.0–2.14)
0.74
CVR (mmHg/mL/min/g)
At rest
124.4 (107.8–137.0)
112.8 (97.1–134.3)
0.19
During CPT
104.9 (88.9–124.4)
128.2 (110–140)
0.001
Δ change to CPT from rest
−19.91((−31.4)–(−6.0))
5.81 (−5.6–17.1)
<0.0001
Pharmacologic vasodilation
37.9 (32.9–45.9)
42.7 (36.7–53.6)
0.03
Hemodynamics at rest
Heart rate (beats/min)
62 (56.5–69)
66 (60–73)
0.01
Systolic blood pressure (mm Hg)
116.5 (110.5–126)
122 (110–132)
0.10
RPP
7090 (6321–7727)
7788 (7080–9000)
0.006
CPT
Heart rate (beats/min)
70 (61.5–79)
73.5 (68–80)
0.01
Systolic blood pressure (mm Hg)
135 (126.5–146)
148 (131–157)
0.02
RPP
9300 (8165–10500)
10804 (9324–12480)
0.004
ΔRPP (CPT-rest)
2144 (1102–2837)
2745 (1228–3671)
0.20
Pharmacologic vasodilation
Heart rate (beats/min)
85 (76.5–91)
87 (82–99)
0.05
Systolic blood pressure (mm Hg)
114 (109–121)
120 (115–130)
0.0005
RPP
9528 (8391–10556)
11171 (9914–12178)
<0.0001
ΔRPP (pharmacologic rest)
2273 (1498–3757)
2800 (2035–4283)
0.18
Values are median (Q1, Q3). MBF: myocardial blood flow; NMBF: normalized MBF; MFR: myocardial flow reserve; CVR: coronary vascular resistance; RPP: rate pressure products. P values according to Mann-Whitney U test for continuous values and to exact bilateral Fischer test for proportions.
