Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals

Table 3

Respective predictive accuracies of anti-apoA-1 IgG and Framingham Risk Score (FRS) for the presence of CAC lesion and the presence of coronary endothelial dysfunction.

ROC curve analyses	Nonobese subjects (𝑛=48)	Obese subjects (𝑛=43)
	Area under the curve (95% CI), P value	Area under the curve (95% CI), P value
Abnormal coronary artery calcium score prediction (>0)
Anti-apoA-1 IgG	0.54 (0.24–0.83), P = 0.41	0.79 (0.54–1.0), P = 0.01
FRS	0.83 (0.69–0.98), P < 0.0001	0.85 (0.68–100), P < 0.0001
Anti-apoA-1 IgG + FRS	0.79 (0.63–0.95), P = 0.0002	0.88 (0.70–100), P < 0.0001
hs-CRP	0.52 (0.28–0.76), P = 0.43	0.64 (0.36–0.92), P = 0.17
Coronary endothelial dysfunction prediction; (ΔMBF during CPT < 30 mL/min/g)
Anti-apoA-1 IgG	0.51 (0.31–0.70), P = 0.47	0.68 (0.10–100), P = 0.24
FRS	0.73 (0.59–0.87), P = 0.0006	0.87 (0.80–0.94), P < 0.0001
hs-CRP	0.53 (0.35–0.71), P = 0.36	0.60 (0.20–0.80), P = 0.30